cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity

cAMP and mTOR signalling pathways control a number of critical cellular processes including metabolism, protein synthesis, proliferation and cell survival and therefore understanding the signalling events which integrate these two signalling pathways is of particular interest. In this study, we show...

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Autores principales: Xie, Jianling, Ponuwei, Godwin A., Moore, Claire E., Willars, Gary B., Tee, Andrew R., Herbert, Terence P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier Science Ltd 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189512/
https://ncbi.nlm.nih.gov/pubmed/21763421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2011.06.025
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