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High-Precision, In Vitro Validation of the Sequestration Mechanism for Generating Ultrasensitive Dose-Response Curves in Regulatory Networks

Our ability to recreate complex biochemical mechanisms in designed, artificial systems provides a stringent test of our understanding of these mechanisms and opens the door to their exploitation in artificial biotechnologies. Motivated by this philosophy, here we have recapitulated in vitro the “tar...

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Detalhes bibliográficos
Main Authors: Ricci, Francesco, Vallée-Bélisle, Alexis, Plaxco, Kevin W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188500/
https://ncbi.nlm.nih.gov/pubmed/21998566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002171
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