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The rational design of allosteric inhibitors and activators using the population-shift model: in vitro validation and application to an artificial biosensor
The population-shift mechanism can be used to rationally re-engineer structure-switching biosensors to enable their allosteric inhibition and activation. As a proof-of-principle example of this we have introduced distal allosteric sites into molecular beacons, an optical sensor for the detection of...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3523727/ https://ncbi.nlm.nih.gov/pubmed/22924432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja304672h |
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