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Allosterically tunable, DNA-based switches triggered by heavy metals
Here we demonstrate the rational design of allosterically controllable, metal-ion-triggered molecular switches. Specifically, we designed DNA sequences that adopt two low energy conformations, one of which does not bind to the target ion and the other of which contains mismatches sites serving as sp...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3831027/ https://ncbi.nlm.nih.gov/pubmed/23971651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja404653q |
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