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Allosterically tunable, DNA-based switches triggered by heavy metals

Here we demonstrate the rational design of allosterically controllable, metal-ion-triggered molecular switches. Specifically, we designed DNA sequences that adopt two low energy conformations, one of which does not bind to the target ion and the other of which contains mismatches sites serving as sp...

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Библиографические подробности
Главные авторы: Porchetta, Alessandro, Vallée-Bélisle, Alexis, Plaxco, Kevin W., Ricci, Francesco
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831027/
https://ncbi.nlm.nih.gov/pubmed/23971651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja404653q
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