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Using distal site mutations and allosteric inhibition to tune, extend and narrow the useful dynamic range of aptamer-based sensors
Here we demonstrate multiple, complementary approaches by which to tune, extend or narrow the dynamic range of aptamer-based sensors. Specifically, we have employed both distal site mutations and allosteric control to tune the affinity and dynamic range of a fluorescent aptamer beacon. We show that...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3866043/ https://ncbi.nlm.nih.gov/pubmed/23215257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja310585e |
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