An Angiotensin I-Converting Enzyme Mutation (Y465D) Causes a Dramatic Increase in Blood ACE via Accelerated ACE Shedding

BACKGROUND: Angiotensin I-converting enzyme (ACE) metabolizes a range of peptidic substrates and plays a key role in blood pressure regulation and vascular remodeling. Thus, elevated ACE levels may be associated with an increased risk for different cardiovascular or respiratory diseases. Previously,...

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Main Authors: Danilov, Sergei M., Gordon, Kerry, Nesterovitch, Andrew B., Lünsdorf, Heinrich, Chen, Zhenlong, Castellon, Maricela, Popova, Isolda A., Kalinin, Sergey, Mendonca, Emma, Petukhov, Pavel A., Schwartz, David E., Minshall, Richard D., Sturrock, Edward D.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187827/
https://ncbi.nlm.nih.gov/pubmed/21998728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025952
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