An Angiotensin I-Converting Enzyme Mutation (Y465D) Causes a Dramatic Increase in Blood ACE via Accelerated ACE Shedding

BACKGROUND: Angiotensin I-converting enzyme (ACE) metabolizes a range of peptidic substrates and plays a key role in blood pressure regulation and vascular remodeling. Thus, elevated ACE levels may be associated with an increased risk for different cardiovascular or respiratory diseases. Previously,...

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Главные авторы: Danilov, Sergei M., Gordon, Kerry, Nesterovitch, Andrew B., Lünsdorf, Heinrich, Chen, Zhenlong, Castellon, Maricela, Popova, Isolda A., Kalinin, Sergey, Mendonca, Emma, Petukhov, Pavel A., Schwartz, David E., Minshall, Richard D., Sturrock, Edward D.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2011
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187827/
https://ncbi.nlm.nih.gov/pubmed/21998728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025952
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