Angiotensin I-Converting Enzyme Gln1069Arg Mutation Impairs Trafficking to the Cell Surface Resulting in Selective Denaturation of the C-Domain

BACKGROUND: Angiotensin-converting enzyme (ACE; Kininase II; CD143) hydrolyzes small peptides such as angiotensin I, bradykinin, substance P, LH-RH and several others and thus plays a key role in blood pressure regulation and vascular remodeling. Complete absence of ACE in humans leads to renal tubu...

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Autors principals: Danilov, Sergei M., Kalinin, Sergey, Chen, Zhenlong, Vinokour, Elena I., Nesterovitch, Andrew B., Schwartz, David E., Gribouval, Olivier, Gubler, Marie-Claire, Minshall, Richard D.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862704/
https://ncbi.nlm.nih.gov/pubmed/20454656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010438
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