Polytopic membrane protein folding at L17 in the ribosome tunnel initiates cyclical changes at the translocon

Multi-spanning membrane protein loops are directed alternately into the cytosol or ER lumen during cotranslational integration. Nascent chain exposure is switched after a newly synthesized transmembrane segment (TMS) enters the ribosomal tunnel. FRET measurements revealed that each TMS is initially...

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Detalhes bibliográficos
Main Authors: Lin, Pen-Jen, Jongsma, Candice G., Pool, Martin R., Johnson, Arthur E.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187706/
https://ncbi.nlm.nih.gov/pubmed/21949410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201103118
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