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Transmembrane segments of nascent polytopic membrane proteins control cytosol/ER targeting during membrane integration
During cotranslational integration of a eukaryotic multispanning polytopic membrane protein (PMP), its hydrophilic loops are alternately directed to opposite sides of the ER membrane. Exposure of fluorescently labeled nascent PMP to the cytosol or ER lumen was detected by collisional quenching of it...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3187712/ https://ncbi.nlm.nih.gov/pubmed/21949411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201103117 |
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