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Membrane Protein TM Segments Are Retained at the Translocon during Integration until the Nascent Chain Cues FRET-detected Release into the Lipid Phase
Most membrane proteins are integrated cotranslationally into the ER membrane at the translocon where nonpolar nascent protein transmembrane segments (TMSs) are widely believed to partition directly into the nonpolar membrane interior. However, a FRET approach that monitors the separation between a f...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3496027/ https://ncbi.nlm.nih.gov/pubmed/23022384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.08.023 |
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