The Ribosome-Sec61 Translocon Complex Forms a Cytosolically Restricted Environment for Early Polytopic Membrane Protein Folding

Transmembrane topology of polytopic membrane proteins (PMPs) is established in the endoplasmic reticulum (ER) by the ribosome Sec61-translocon complex (RTC) through iterative cycles of translocation initiation and termination. It remains unknown, however, whether tertiary folding of transmembrane do...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Patterson, Melissa A., Bandyopadhyay, Anannya, Devaraneni, Prasanna K., Woodward, Josha, Rooney, LeeAnn, Yang, Zhongying, Skach, William R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Protein Synthesis and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661407/
https://ncbi.nlm.nih.gov/pubmed/26254469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.672261
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