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Cotranslational Folding Inhibits Translocation from Within the Ribosome–Sec61 Translocon Complex
Eukaryotic secretory proteins cross the endoplasmic reticulum (ER) membrane through a protein conducting channel contained within the Ribosome–Sec61Translocon Complex (RTC). Using a zinc-finger sequence as a folding switch, we show that cotranslational folding of a secretory passenger inhibits trans...
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| Publicado no: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4351553/ https://ncbi.nlm.nih.gov/pubmed/24561504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2779 |
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