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Molecular Basis for the Selectivity of Antituberculosis Compounds Capreomycin and Viomycin

Capreomycin and the structurally similar compound viomycin are cyclic peptide antibiotics which are particularly active against Mycobacterium tuberculosis, including multidrug resistant strains. Both antibiotics bind across the ribosomal interface involving 23S rRNA helix 69 (H69) and 16S rRNA helix...

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Bibliografske podrobnosti
Main Authors: Akbergenov, Rashid, Shcherbakov, Dmitri, Matt, Tanja, Duscha, Stefan, Meyer, Martin, Wilson, Daniel N., Böttger, Erik C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187005/
https://ncbi.nlm.nih.gov/pubmed/21768509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00628-11
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