Molecular Basis for the Selectivity of Antituberculosis Compounds Capreomycin and Viomycin

Capreomycin and the structurally similar compound viomycin are cyclic peptide antibiotics which are particularly active against Mycobacterium tuberculosis, including multidrug resistant strains. Both antibiotics bind across the ribosomal interface involving 23S rRNA helix 69 (H69) and 16S rRNA helix...

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Main Authors: Akbergenov, Rashid, Shcherbakov, Dmitri, Matt, Tanja, Duscha, Stefan, Meyer, Martin, Wilson, Daniel N., Böttger, Erik C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2011
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Mechanisms of Action: Physiological Effects
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187005/
https://ncbi.nlm.nih.gov/pubmed/21768509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00628-11
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