Molecular Basis for the Selectivity of Antituberculosis Compounds Capreomycin and Viomycin

Capreomycin and the structurally similar compound viomycin are cyclic peptide antibiotics which are particularly active against Mycobacterium tuberculosis, including multidrug resistant strains. Both antibiotics bind across the ribosomal interface involving 23S rRNA helix 69 (H69) and 16S rRNA helix...

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Autors principals: Akbergenov, Rashid, Shcherbakov, Dmitri, Matt, Tanja, Duscha, Stefan, Meyer, Martin, Wilson, Daniel N., Böttger, Erik C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
Matèries:
Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187005/
https://ncbi.nlm.nih.gov/pubmed/21768509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00628-11
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