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Two Endogenous Antiangiogenic Inhibitors, Endostatin and Angiostatin, Demonstrate Biphasic Curves in their Antitumor Profiles

Angiogenesis refers to growth of blood vessels from pre-existing ones. In 1971, Folkman proposed that by choking off the blood supply to tumors, they are starved, leading to their demise. A few years ago, the monoclonal antibody Avastin became the first antiangiogenic biological approved by FDA, for...

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Bibliographische Detailangaben
Hauptverfasser: Javaherian, Kashi, Lee, Tong-Young, Tjin Tham Sjin, Robert M., Parris, George E., Hlatky, Lynn
Format: Artigo
Sprache:Inglês
Veröffentlicht: International Hormesis Society 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186931/
https://ncbi.nlm.nih.gov/pubmed/22013399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2203/dose-response.10-020.Javaherian
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