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Angiostatin regulates the expression of antiangiogenic and proapoptotic pathways via targeted inhibition of mitochondrial proteins

Angiostatin, a proteolytic fragment of plasminogen, is a potent endogenous antiangiogenic agent. The molecular mechanisms governing angiostatin's antiangiogenic and antitumor effects are not well understood. Here, we report the identification of mitochondrial compartment as the ultimate target...

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Sonraí Bibleagrafaíochta
Main Authors: Lee, Tong-Young, Muschal, Stefan, Pravda, Elke A., Folkman, Judah, Abdollahi, Amir, Javaherian, Kashi
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738581/
https://ncbi.nlm.nih.gov/pubmed/19465692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-12-197236
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