Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Non-Alcoholic Steatohepatitis

BACKGROUND & AIMS: Type-2 diabetes and non-alcoholic steatohepatitis (NASH) are associated with insulin resistance and disordered cholesterol homeostasis. We investigated the basis for hepatic cholesterol accumulation with insulin resistance and its relevance to pathogenesis of NASH. METHODS: Al...

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Autori principali: Van Rooyen, Derrick M, Larter, Claire Z, Haigh, W Geoffrey, Yeh, Matthew M, Ioannou, George, Kuver, Rahul, Lee, Sum P, Teoh, Narci C, Farrell, Geoffrey C
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186822/
https://ncbi.nlm.nih.gov/pubmed/21703998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.06.040
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