Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Non-Alcoholic Steatohepatitis

BACKGROUND & AIMS: Type-2 diabetes and non-alcoholic steatohepatitis (NASH) are associated with insulin resistance and disordered cholesterol homeostasis. We investigated the basis for hepatic cholesterol accumulation with insulin resistance and its relevance to pathogenesis of NASH. METHODS: Al...

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Detalhes bibliográficos
Main Authors: Van Rooyen, Derrick M, Larter, Claire Z, Haigh, W Geoffrey, Yeh, Matthew M, Ioannou, George, Kuver, Rahul, Lee, Sum P, Teoh, Narci C, Farrell, Geoffrey C
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186822/
https://ncbi.nlm.nih.gov/pubmed/21703998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.06.040
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