Obesity and diabetes accelerate hepatocarcinogenesis via hepatocyte proliferation independent of NF-κB or Akt/mTORC1

BACKGROUND: There are strong links between obesity, diabetes and hepatocellular carcinoma (HCC), but molecular mechanisms remain unclear. AIM: We tested the proposed involvement of NF-κB, IL-6/STAT3 and Akt/mTORC1 before onset (at 3 months) and at onset (6 months) of accelerated hepatocarcinogenesis...

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Publicado en:J Clin Transl Res
Main Authors: Arfianti, Evi, Larter, Claire Z, Lee, Seungsoo, Barn, Vanessa, Haigh, Geoffrey, Yeh, Matthew M., Ioannou, George N., Teoh, Narci C., Farrell, Geoffrey C.
Formato: Artigo
Idioma:Inglês
Publicado: Whioce Publishing Pte. Ltd. 2016
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410642/
https://ncbi.nlm.nih.gov/pubmed/30873458
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