Native mass spectrometry provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS

The DNA mismatch repair protein MutS recognizes mispaired bases in DNA and initiates repair in an ATP-dependent manner. Understanding of the allosteric coupling between DNA mismatch recognition and two asymmetric nucleotide binding sites at opposing sides of the MutS dimer requires identification of...

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Detalhes bibliográficos
Main Authors: Monti, Maria Chiara, Cohen, Serge X., Fish, Alexander, Winterwerp, Herrie H. K., Barendregt, Arjan, Friedhoff, Peter, Perrakis, Anastassis, Heck, Albert J. R., Sixma, Titia K., van den Heuvel, Robert H. H., Lebbink, Joyce H. G.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3185415/
https://ncbi.nlm.nih.gov/pubmed/21737427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr498
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