Development of Diabetes in Lean Ncb5or-Null Mice is Associated with Manifestations of Endoplasmic Reticulum and Oxidative Stress in Beta Cells

NADH-cytochrome b5 oxidoreductase (Ncb5or) is an endoplasmic reticulum (ER)-associated redox enzyme involved in fatty acid metabolism, and phenotypic abnormalities of Ncb5or(−/−) mice include diabetes and lipoatrophy. These mice are lean and insulin-sensitive but become hyperglycemic at age 7 weeks...

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Main Authors: Wang, WenFang, Guo, Ying, Xu, Ming, Huang, Han-Hung, Novikova, Lesya, Larade, Kevin, Jiang, Zhi-Gang, Thayer, Terri C., Frontera, Jennifer R., Aires, Daniel, Ding, Helin, Turk, John, Mathews, Clayton E., Bunn, H. Franklin, Stehno-Bittel, Lisa, Zhu, Hao
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3185181/
https://ncbi.nlm.nih.gov/pubmed/21839170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2011.07.016
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