Beta-Cell Injury in Ncb5or-null Mice is Exacerbated by Consumption of a High-Fat Diet

NADH-cytochrome b5 oxidoreductase (Ncb5or) in endoplasmic reticulum (ER) is involved in fatty acid metabolism, and Ncb5or(−/−) mice fed standard chow (SC) are insulin-sensitive but weigh less than wild type (WT) littermates. Ncb5or(−/−) mice develop hyperglycemia at about age 7 weeks due to β-cell d...

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Detalhes bibliográficos
Main Authors: Guo, Ying, Xu, Ming, Deng, Bin, Frontera, Jennifer R., Kover, Karen L., Aires, Daniel, Ding, Helin, Carlson, Susan E., Turk, John, Wang, WenFang, Zhu, Hao
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348618/
https://ncbi.nlm.nih.gov/pubmed/22582025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ejlt.201100309
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