Loss of Ncb5or Results in Impaired Fatty Acid Desaturation, Lipoatrophy, and Diabetes

Targeted ablation of the novel flavoheme reductase Ncb5or knock-out (KO) results in progressive loss of pancreatic β-cells and white adipose tissue over time. Lipoatrophy persisted in KO animals in which the confounding metabolic effects of diabetes were eliminated by islet transplantation (transpla...

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Huvudupphovsmän: Larade, Kevin, Jiang, Zhigang, Zhang, Yongzhao, Wang, WenFang, Bonner-Weir, Susan, Zhu, Hao, Bunn, H. Franklin
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2008
Ämnen:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570878/
https://ncbi.nlm.nih.gov/pubmed/18682384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804645200
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