Liver-specific Loss of Long Chain Acyl-CoA Synthetase-1 Decreases Triacylglycerol Synthesis and β-Oxidation and Alters Phospholipid Fatty Acid Composition

In mammals, a family of five acyl-CoA synthetases (ACSLs), each the product of a separate gene, activates long chain fatty acids to form acyl-CoAs. Because the ACSL isoforms have overlapping preferences for fatty acid chain length and saturation and are expressed in many of the same tissues, the ind...

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Bibliografiske detaljer
Main Authors: Li, Lei O., Ellis, Jessica M., Paich, Heather A., Wang, Shuli, Gong, Nan, Altshuller, George, Thresher, Randy J., Koves, Timothy R., Watkins, Steven M., Muoio, Deborah M., Cline, Gary W., Shulman, Gerald I., Coleman, Rosalind A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788832/
https://ncbi.nlm.nih.gov/pubmed/19648649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.022467
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