Silencing of Hepatic Fatty Acid Transporter Protein 5 in Vivo Reverses Diet-induced Non-alcoholic Fatty Liver Disease and Improves Hyperglycemia

Non-alcoholic fatty liver disease is a serious health problem linked to obesity and type 2 diabetes. To investigate the biological outcome and therapeutic potential of hepatic fatty acid uptake inhibition, we utilized an adeno-associated virus-mediated RNA interference technique to knock down the ex...

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Detalhes bibliográficos
Main Authors: Doege, Holger, Grimm, Dirk, Falcon, Alaric, Tsang, Bernice, Storm, Theresa A., Xu, Hui, Ortegon, Angelica M., Kazantzis, Melissa, Kay, Mark A., Stahl, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494916/
https://ncbi.nlm.nih.gov/pubmed/18524776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803510200
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