Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice

Acid sphingomyelinase plays important roles in ceramide homeostasis, which has been proposed to be linked to insulin resistance. To test this association in vivo, acid sphingomyelinase deletion (asm(–/–)) was transferred to mice lacking the low density lipoprotein receptor (ldlr(–/–)), and then offs...

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Detalhes bibliográficos
Main Authors: Deevska, Gergana M., Rozenova, Krassimira A., Giltiay, Natalia V., Chambers, Melissa A., White, James, Boyanovsky, Boris B., Wei, Jia, Daugherty, Alan, Smart, Eric J., Reid, Michael B., Merrill, Alfred H., Nikolova-Karakashian, Mariana
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659194/
https://ncbi.nlm.nih.gov/pubmed/19074137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807800200
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