Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53

Activation of p53 by DNA damage results in either cell cycle arrest, allowing DNA repair and cell survival, or induction of apoptosis. As these opposite outcomes are both mediated by p53 stabilization, additional mechanisms to determine this decision must exist. Here we show that glycogen synthase k...

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Auteurs principaux: Charvet, Céline, Wissler, Manuela, Brauns-Schubert, Prisca, Wang, Shang-Jui, Tang, Yi, Sigloch, Florian C., Mellert, Hestia, Brandenburg, Martin, Lindner, Silke E., Breit, Bernhard, Green, Douglas R., McMahon, Steven B., Borner, Christoph, Gu, Wei, Maurer, Ulrich
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184637/
https://ncbi.nlm.nih.gov/pubmed/21658600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.03.033
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