CDK9‐mediated phosphorylation controls the interaction of TIP60 with the transcriptional machinery

The acetyltransferase TIP60 is regulated by phosphorylation, and we have previously shown that phosphorylation of TIP60 on S86 by GSK‐3 promotes p53‐mediated induction of the BCL‐2 protein PUMA. TIP60 phosphorylation by GSK‐3 requires a priming phosphorylation on S90, and here, we identify CDK9 as a...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Brauns‐Schubert, Prisca, Schubert, Florian, Wissler, Manuela, Weiss, Martina, Schlicher, Lisa, Bessler, Simon, Safavi, Mariam, Miething, Cornelius, Borner, Christoph, Brummer, Tilman, Maurer, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797957/
https://ncbi.nlm.nih.gov/pubmed/29335245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201744311
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