Phase I Randomised Clinical Trial of an HIV-1(CN54), Clade C, Trimeric Envelope Vaccine Candidate Delivered Vaginally

We conducted a phase 1 double-blind randomised controlled trial (RCT) of a HIV-1 envelope protein (CN54 gp140) candidate vaccine delivered vaginally to assess immunogenicity and safety. It was hypothesised that repeated delivery of gp140 may facilitate antigen uptake and presentation at this mucosal...

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Bibliografiske detaljer
Main Authors: Lewis, David J., Fraser, Carol A., Mahmoud, Abdel N., Wiggins, Rebecca C., Woodrow, Maria, Cope, Alethea, Cai, Chun, Giemza, Rafaela, Jeffs, Simon A., Manoussaka, Maria, Cole, Tom, Cranage, Martin P., Shattock, Robin J., Lacey, Charles J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184147/
https://ncbi.nlm.nih.gov/pubmed/21984924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025165
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