Antibody responses after intravaginal immunisation with trimeric HIV-1(CN54) clade C gp140 in Carbopol gel are augmented by systemic priming or boosting with an adjuvanted formulation

Optimum strategies to elicit and maintain antibodies at mucosal portals of virus entry are critical for the development of vaccines against human immunodeficiency virus (HIV). Here we show in non-human primates that a novel regimen of repeated intravaginal delivery of a non-adjuvanted, soluble recom...

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Autors principals: Cranage, Martin P., Fraser, Carol A., Cope, Alethea, McKay, Paul F., Seaman, Michael S., Cole, Tom, Mahmoud, A. Nasir, Hall, Joanna, Giles, Elaine, Voss, Gerald, Page, Mark, Almond, Neil, Shattock, Robin J.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Science 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060343/
https://ncbi.nlm.nih.gov/pubmed/21187177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2010.12.034
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