Antibody responses after intravaginal immunisation with trimeric HIV-1(CN54) clade C gp140 in Carbopol gel are augmented by systemic priming or boosting with an adjuvanted formulation

Optimum strategies to elicit and maintain antibodies at mucosal portals of virus entry are critical for the development of vaccines against human immunodeficiency virus (HIV). Here we show in non-human primates that a novel regimen of repeated intravaginal delivery of a non-adjuvanted, soluble recom...

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Hauptverfasser: Cranage, Martin P., Fraser, Carol A., Cope, Alethea, McKay, Paul F., Seaman, Michael S., Cole, Tom, Mahmoud, A. Nasir, Hall, Joanna, Giles, Elaine, Voss, Gerald, Page, Mark, Almond, Neil, Shattock, Robin J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Science 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060343/
https://ncbi.nlm.nih.gov/pubmed/21187177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2010.12.034
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