Phase I Randomised Clinical Trial of an HIV-1(CN54), Clade C, Trimeric Envelope Vaccine Candidate Delivered Vaginally

We conducted a phase 1 double-blind randomised controlled trial (RCT) of a HIV-1 envelope protein (CN54 gp140) candidate vaccine delivered vaginally to assess immunogenicity and safety. It was hypothesised that repeated delivery of gp140 may facilitate antigen uptake and presentation at this mucosal...

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Detalhes bibliográficos
Main Authors: Lewis, David J., Fraser, Carol A., Mahmoud, Abdel N., Wiggins, Rebecca C., Woodrow, Maria, Cope, Alethea, Cai, Chun, Giemza, Rafaela, Jeffs, Simon A., Manoussaka, Maria, Cole, Tom, Cranage, Martin P., Shattock, Robin J., Lacey, Charles J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184147/
https://ncbi.nlm.nih.gov/pubmed/21984924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025165
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