Vaginal delivery of the recombinant HIV-1 clade-C trimeric gp140 envelope protein CN54gp140 within novel rheologically structured vehicles elicits specific immune responses

Rheologically structured vehicle (RSV) gels were developed as delivery systems for vaginal mucosal vaccination with an HIV-1 envelope glycoprotein (CN54gp140). RSVs comprised a mucoadhesive matrix-forming and vaginal fluid absorbing polymer. The mucoadhesive and rheological properties of the RSVs we...

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Main Authors: Curran, Rhonda M., Donnelly, Louise, Morrow, Ryan J., Fraser, Carol, Andrews, Gavin, Cranage, Martin, Malcolm, R. Karl, Shattock, Robin J., Woolfson, A. David
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier Science 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824087/
https://ncbi.nlm.nih.gov/pubmed/19747994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.08.088
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