Breadth of Neutralizing Antibodies Elicited by Stable, Homogeneous Clade A and Clade C HIV-1 gp140 Envelope Trimers in Guinea Pigs

The native envelope (Env) spike on the surface of human immunodeficiency virus type 1 (HIV-1) is trimeric, and thus trimeric Env vaccine immunogens are currently being explored in preclinical immunogenicity studies. Key challenges have included the production and purification of biochemically homoge...

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Autors principals: Nkolola, Joseph P., Peng, Hanqin, Settembre, Ethan C., Freeman, Michael, Grandpre, Lauren E., Devoy, Colleen, Lynch, Diana M., La Porte, Annalena, Simmons, Nathaniel L., Bradley, Ritu, Montefiori, David C., Seaman, Michael S., Chen, Bing, Barouch, Dan H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838122/
https://ncbi.nlm.nih.gov/pubmed/20053749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02252-09
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