HIV-1 envelope trimer elicits more potent neutralizing antibody responses than monomeric gp120

HIV-1 envelope glycoprotein is the primary target for HIV-1–specific antibodies. The native HIV-1 envelope spike on the virion surface is a trimer, but trimeric gp140 and monomeric gp120 currently are believed to induce comparable immune responses. Indeed, most studies on the immunogenicity of HIV-1...

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Autores principales: Kovacs, James M., Nkolola, Joseph P., Peng, Hanqin, Cheung, Ann, Perry, James, Miller, Caroline A., Seaman, Michael S., Barouch, Dan H., Chen, Bing
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2012
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409750/
https://ncbi.nlm.nih.gov/pubmed/22773820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204533109
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