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Crystal structure of amyloid precursor-like protein 1 and heparin complex suggests a dual role of heparin in E2 dimerization
Mutations in amyloid precursor protein (APP) are associated with familial Alzheimer’s disease. Recent development suggests that homo- and heterodimerization of APP and APP-like proteins (APLPs), which are enhanced by heparan sulfate binding, may play a role in signal transduction and cell adhesion....
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3182750/ https://ncbi.nlm.nih.gov/pubmed/21930949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1103407108 |
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