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Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein
The amyloid precursor protein (APP) is the key player in Alzheimer’s disease pathology, yet APP and its analogues are also essential for neuronal development and cell homeostasis in mammals. We have determined the crystal structure of the entire N-terminal APP-E1 domain consisting of the growth fact...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2851805/ https://ncbi.nlm.nih.gov/pubmed/20212142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911326107 |
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