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Analysis of the Overall Structure of the Multi-Domain Amyloid Precursor Protein (APP)
The amyloid precursor protein (APP) and its processing by the α-, β- and γ-secretases is widely believed to play a central role during the development of Alzheimer´s disease. The three-dimensional structure of the entire protein, its physiologic function and the regulation of its proteolytic process...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3852973/ https://ncbi.nlm.nih.gov/pubmed/24324731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081926 |
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