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Mitochondrial Mechanism of Microvascular Endothelial Cells Apoptosis in Hyperhomocysteinemia

An elevated level of homocysteine (Hcy) limits the growth and induces apoptosis. However, the mechanism of Hcy-induced programmed cell death in endothelial cells is largely unknown. We hypothesize that Hcy induces intracellular reactive oxygen species (ROS) production that leads to the loss of trans...

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Bibliographic Details
Main Authors: Tyagi, Neetu, Ovechkin, Alexander V., Lominadze, David, Moshal, Karni S., Tyagi, Suresh C.
Format: Artigo
Language:Inglês
Published: 2006
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182486/
https://ncbi.nlm.nih.gov/pubmed/16514665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.20837
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