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GABA Receptors Ameliorate Hcy-Mediated Integrin Shedding and Constrictive Collagen Remodeling in Microvascular Endothelial Cells
Mammalian endothelial cells are deficient in cystathionine β synthetase (CBS) activity, which is responsible for homocysteine (Hcy) clearance. This deficiency makes the endothelium the prime target for Hcy toxicity. Hcy induces integrin shedding in microvascular endothelial cells (MVEC) by increasin...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3182507/ https://ncbi.nlm.nih.gov/pubmed/16757816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1385/CBB:45:2:157 |
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