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Homocysteine alters cerebral microvascular integrity and causes remodeling by antagonizing GABA-A receptor

High levels of homocysteine (Hcy), known as hyperhomocysteinemia (HHcy), are associated with cerebrovascular diseases, such as vascualr dementia, stroke, and Alzheimer's disease. The -amino butyric acid (GABA) is a inhibitory neurotransmitter and a ligand of GABA-A receptor. By inhibiting excit...

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Hlavní autoři: Lominadze, David, Tyagi, Neetu, Sen, Utpal, Ovechkin, Alexander, Tyagi, Suresh C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3484206/
https://ncbi.nlm.nih.gov/pubmed/22886392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11010-012-1425-5
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