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Calcium-dependent block of P2X7 receptor channel function is allosteric
Among purinergic P2X receptor (P2XR) channels, the P2X7R exhibits the most complex gating kinetics; the binding of orthosteric agonists at the ectodomain induces a conformational change in the receptor complex that favors a gating transition from closed to open and dilated states. Bath Ca(2+) affect...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3182445/ https://ncbi.nlm.nih.gov/pubmed/21911484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201110647 |
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