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Defective Myofibroblast Formation from Mesenchymal Stem Cells in the Aging Murine Heart: Rescue by Activation of the AMPK Pathway

Aged mice in a murine model of myocardial infarction exhibit less effective myocardial repair. We hypothesized that the deficiency arises from altered lineage choice of endogenous mesenchymal stem cells (MSCs) and faulty maturation of myofibroblasts. Examination of cardiac MSCs revealed a substantia...

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Detaylı Bibliyografya
Asıl Yazarlar: Cieslik, Katarzyna A., Trial, JoAnn, Entman, Mark L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Investigative Pathology 2011
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3181380/
https://ncbi.nlm.nih.gov/pubmed/21819956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.06.022
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