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Mesenchymal Stem Cell-derived Inflammatory Fibroblasts Mediate Interstitial Fibrosis in the Aging Heart
Pathologic fibrosis in the aging mouse heart is associated with dysregulated resident mesenchymal stem cells (MSC) arising from reduced stemness and aberrant differentiation into dysfunctional inflammatory fibroblasts. Fibroblasts derived from aging MSC secrete higher levels of 1) collagen type 1 (C...
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| Publicado no: | J Mol Cell Cardiol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4764495/ https://ncbi.nlm.nih.gov/pubmed/26718722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.12.017 |
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