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Adverse Fibrosis in the Aging Heart Depends on Signaling Between Myeloid and Mesenchymal Cells; Role of Inflammatory Fibroblasts

Aging has been associated with adverse fibrosis. Here we formulate a new hypothesis and present new evidence that unresponsiveness of mesenchymal stem cells (MSC) and fibroblasts to transforming growth factor beta (TGF-β), due to reduced expression of TGF-β receptor I (TβRI), provides a foundation f...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Cieslik, Katarzyna A., Trial, JoAnn, Crawford, Jeffrey R., Taffet, George E., Entman, Mark L.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3995828/
https://ncbi.nlm.nih.gov/pubmed/24184998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2013.10.017
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