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Adverse Fibrosis in the Aging Heart Depends on Signaling Between Myeloid and Mesenchymal Cells; Role of Inflammatory Fibroblasts
Aging has been associated with adverse fibrosis. Here we formulate a new hypothesis and present new evidence that unresponsiveness of mesenchymal stem cells (MSC) and fibroblasts to transforming growth factor beta (TGF-β), due to reduced expression of TGF-β receptor I (TβRI), provides a foundation f...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3995828/ https://ncbi.nlm.nih.gov/pubmed/24184998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2013.10.017 |
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