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Mesenchymal Stem Cell-derived Inflammatory Fibroblasts Mediate Interstitial Fibrosis in the Aging Heart

Pathologic fibrosis in the aging mouse heart is associated with dysregulated resident mesenchymal stem cells (MSC) arising from reduced stemness and aberrant differentiation into dysfunctional inflammatory fibroblasts. Fibroblasts derived from aging MSC secrete higher levels of 1) collagen type 1 (C...

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Bibliografiske detaljer
Udgivet i:J Mol Cell Cardiol
Main Authors: Trial, JoAnn, Entman, Mark L., Cieslik, Katarzyna A.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764495/
https://ncbi.nlm.nih.gov/pubmed/26718722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.12.017
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