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Defective Myofibroblast Formation from Mesenchymal Stem Cells in the Aging Murine Heart: Rescue by Activation of the AMPK Pathway
Aged mice in a murine model of myocardial infarction exhibit less effective myocardial repair. We hypothesized that the deficiency arises from altered lineage choice of endogenous mesenchymal stem cells (MSCs) and faulty maturation of myofibroblasts. Examination of cardiac MSCs revealed a substantia...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Investigative Pathology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3181380/ https://ncbi.nlm.nih.gov/pubmed/21819956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.06.022 |
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