AICAR-dependent AMPK Activation Improves Scar Formation in the Aged Heart in a Murine Model of Reperfused Myocardial Infarction

We have demonstrated that scar formation after myocardial infarction (MI) is associated with an endogenous pool of CD44(pos)CD45(neg) multipotential mesenchymal stem cells (MSC). MSC differentiate into fibroblasts secreting collagen that forms a scar and mature into myofibroblasts that express alpha...

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Autori principali: Cieslik, Katarzyna A., Taffet, George E., Crawford, Jeffrey R., Trial, JoAnn, Osuna, Patricia Mejia, Entman, Mark L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820161/
https://ncbi.nlm.nih.gov/pubmed/23871790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2013.07.005
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