Gene expression signature of c-MYC-immortalized human fibroblasts reveals loss of growth inhibitory response to TGFβ

Cancer cells exhibit the ability to proliferate indefinitely, but paradoxically, overexpression of cellular oncogenes in primary cells can result in a rapid and irreversible cell cycle arrest known as oncogene-induced senescence (OIS). However, we have shown that constitutive overexpression of the o...

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Main Authors: Wang, Myra L, Walsh, Ryan, Robinson, Kristin L, Burchard, Julja, Bartz, Steven R, Cleary, Michele, Galloway, Denise A, Grandori, Carla
Formáid: Artigo
Teanga:Inglês
Foilsithe: Landes Bioscience 2011
Ábhair:
Report
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3180192/
https://ncbi.nlm.nih.gov/pubmed/21720214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.15.16309
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