Gene expression signature of c-MYC-immortalized human fibroblasts reveals loss of growth inhibitory response to TGFβ

Cancer cells exhibit the ability to proliferate indefinitely, but paradoxically, overexpression of cellular oncogenes in primary cells can result in a rapid and irreversible cell cycle arrest known as oncogene-induced senescence (OIS). However, we have shown that constitutive overexpression of the o...

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Detalhes bibliográficos
Main Authors: Wang, Myra L, Walsh, Ryan, Robinson, Kristin L, Burchard, Julja, Bartz, Steven R, Cleary, Michele, Galloway, Denise A, Grandori, Carla
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3180192/
https://ncbi.nlm.nih.gov/pubmed/21720214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.15.16309
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