Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells

A truncated and constitutively active form of the EGF receptor, variant III (EGFRvIII), is a major determinant of tumor growth and progression in glioblastoma multiforme (GBM). Extensive bidirectional crosstalk occurs in the cell-signaling pathways downstream of the EGFR and the urokinase-type plasm...

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Bibliographische Detailangaben
Hauptverfasser: Hu, Jingjing, Jo, Minji, Cavenee, Webster K., Furnari, Frank, VandenBerg, Scott R., Gonias, Steven L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179096/
https://ncbi.nlm.nih.gov/pubmed/21896743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113416108
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